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Recombinant antibody expert
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Cell line for recombinant antibody production

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Hybridoma conversion to CHO expression

Diaorigin
Expert in cell lines and recombinant antibodies

Holder of the SwiMR technology, a scientific team experienced in biotechnology, our goal is to help you advance your research at a lower cost and in less time.
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Re-expression of antibodies without hybridoma

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Rapid recombinant antibody discovery

SwiMR - patented technology

※ Enrich top productive rare cells by 10,000 times; 
※ Cell sorting by flow cytometry, obtain your highest expression mini-pool stable cells in ONE month, ready for industrial scale production; 
※ Monocloning from the top 0.01% mini-pool, one-round 100% get your highest expression monoclonal cell line in THREE months; 
※ Target gene expressed separately from the reporter gene, the latter can be removed from the cell genome (switchable)

Dr. Yu explains...

Dr. Bo Yu, founder of Diaorigin Biotechnology, patent holder of SwiMR and AMR technology, explains the advantages of our technologies.

Recombinant antibodies

A recombinant antibody is a synthetic monoclonal antibody that is generated by recombinant DNA technology; an in vitro alternative to the traditional hybridoma-based technology for creating monoclonal antibodies. Recombinant antibodies are generated outside the immune system using synthetic genes and therefore do not require animal immunization for their production. These synthetic antibodies can be used in all applications and have several advantages compared to traditional animal-derived antibodies.

What are the advantages ?

01

Stablility

Superior Lot-to-Lot Consistency

02

Scalability

Amenable to large-scale production

03

Engineerable

Knowing sequence possible for all engineering

04

Animal-free

Cellular expression avoid the need to use animals

>>> Learn more

DiaBooster Hyper-Expression Plate-forme

Increase expression up to 10 - 15 g/L

DiaBooster CHO-K1A cell line is an adapted suspension cell line derived from CHO-K1, characterized by its ability to produce complex proteins similar to those in humans and its high tolerance for variations in pH, oxygen levels, temperature or cell density. It is capable to expand expression to 10-20 folds after Fed-Batch culture, which makes it ideal for large-scale recombinant antibody manufacturing.

Beacon single B cell sorting

The Beacon single B cell sorting system can introduce thousands of single cells into the nano-level micro-reaction chamber in one experiment through photoelectric positioning technology and microfluidic technology for integrated operations of single cell separation, detection, culture and export.

By using this technology, we are capable to obtain high-affinity monoclonal antibodies within 35 days, greatly accelerates the process of antibody discovery.